The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin...
Comments:low Testosterone associated with insulin resistance, type II diabetes, metabolic syndrome, and increased fat. These will all translate to increased mortality. - Nathan GoodyearTags:low, T,...
View ArticleRegulation of 11beta-HSD genes in human adipose tis... [Obes Res. 2004] -...
Comments:adipocytes increase genetic expression of 11beta-HSD. This increases local cortisol production from cortisone. This plays a pivotal role in obesity. Question: would this play a role in...
View ArticleTissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity
Comments:dysregulated cortisol metabolism plays a role in obesity. This study looked at obese men. Decreased liver 11-betaHSD1 activity was found in the liver, with decreased cortisone to cortisol...
View Article11beta-hydroxysteroid dehydrogenase type 1 an... [Front Horm Res. 2008] -...
Comments:11-betaHSD1 expression and effect is site specific. - Nathan GoodyearHighlights and Sticky Notes:Adipose-selective 11beta -HSD1 transgenic mice exhibited elevated intra-adipose and portal, but...
View ArticleDehydroepiandrosterone reduces preadipocyte proliferation via androgen receptor
Comments:DHEA reduces preadipocytes growth through the androgen receptor. - Nathan GoodyearTags:DHEA, obesity, adipose, tissue, adipocytes, fat, diabetes, androgen, receptorby:Nathan Goodyear
View ArticleEffect of DHEA-sulfate on adiponectin gene expression in adipose tissue from...
Comments:DHEA-S shown to increase genetic expression of adiponectin in human adipose tissue. This has enormous implications on the link between DHEA and insulin resistance induce obesity. This is a...
View ArticleJCI - Chronic inflammation in fat plays a crucial role in the development of...
Comments:how inflammation contributes to obesity. Nice discussion of the inflammatory signaling that leads to obesity. This occurs predominately in white adipose tissue WAT. This leads to insulin...
View ArticleWeb of Knowledge [v.5.3] - Web of Science
Comments:animal model: showed that DHEA treatment resulted in increased adiponectin secretion from fat cells. This occurred with an associated increase in PPAR-gamma receptors. The suggestion is that...
View ArticleRelationship of visceral adipose tissue and glucose disposal is independent...
Comments:Increase in visceral fat reduces glucose "disposal". Translated: as visceral adiposity increases, associated insulin resistance increases glucose levels and all associated metabolic...
View ArticleStimulation of aromatase activity in bre... [Mol Cell Endocrinol. 1994] -...
Comments:inflammatory cytokine, TNF-alpha, increases aromatase activity. This article discusses the increased production of estrone from androstenedione from aromatase activity in fat tissue in the...
View ArticleThe Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory...
Comments:Great review of the current understanding on adipose tissue as a hormone, inflammatory producing organ. - Nathan GoodyearTags:fat, adipose, tissue, inflammation, adipokines, adipocytokines,...
View ArticleLow Grade Chronic Inflammation in Women with Polycystic Ovarian Syndrome
Comments:Women with PCOS have associated increased inflammation. This origin is primarily via adipose tissue and associate adipocytokines (TNF-alpha, and IL-6). CRP elevation, as found in this study,...
View ArticleThe polycystic ovary syndrome per se is not associated with increased chronic...
Comments:This study finds no association between PCOS and inflammation, when matched with age/BMI controls. However, inflammation was associated with increased BMI. Not all women with PCOS are...
View ArticleAdipose Tissue: The New Endocrine Organ?
Comments:fat and obesity becomes a hormone, inflammatory producing organ. Great read. You must be healthy to lose weight, not lose weigh to be healthy. The "fat" in obesity has been link to many of the...
View ArticleJAMA Network | JAMA: The Journal of the American Medical Association |...
Comments:Nurses' Health study analysis finds no increased breast cancer risk with low fat diet. This was a meta-analysis of almost 90,000 women. - Nathan GoodyearTags:breast, cancer, fat, low fat...
View ArticleCaloric restriction increases adiponectin expression by adipose tissue and...
Comments:Calorie restriction increases adiponectin secretion from adipocytes. Another plus of calorie restriction. Remember, adiponectin and insulin are inversely associated. Granted, this is in a...
View ArticleF as in Fat: How Obesity Threatens America's Future 2012 - Trust for...
Comments:Obesity rate of 60%? Just maybe...and very soon. - Nathan GoodyearTags:obesity, fat, overweight, healthby:Nathan Goodyear
View ArticleToll-like receptor signaling links dietary fatty acids to the metabolic syndrome
Comments:high dietary fatty acids linked to metabolic syndrome through TLR. - Nathan GoodyearHighlights and Sticky Notes:Activation of the innate immune system controls macronutrient metabolismthe...
View ArticlePathways of adipose tissue androgen metabolism in women: depot differences...
Comments:aromatase activity is concentrated in subcutaneous and visceral adipose tissue. - Nathan GoodyearTags:aromatase, activity, fat, abdominal, visceral, adipose, tissueby:Nathan Goodyear
View ArticleDiabetology & Metabolic Syndrome | Full text | Visceral adiposity, insulin...
Comments:adipose tissue and it's biological activity contribution to cancer risk. Good review of our current understanding on how adipose tissue increases the favorably of cancer. - Nathan...
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